We primarily work with human iPSC lines differentiated into 3D organoids, as well as 2D mixed and monocultures of neurons, astrocytes and microglia, in order to model how disease-causing MAPT mutations affect cellular function. Computational work includes the generation and analysis of large 'omics datasets, and fine-mapping of human genetic data to understand the consequences of structural variation at the 17q21.31 "MAPT" locus.

The Bowles lab is committed to creating and maintaining an inclusive, diverse and highly collaborative environment. Click around to find out more about who we are and what we do, and feel free to get in touch!