About Us

The Bowles lab is based at the UK Dementia Research Institute at the University of Edinburgh, UK. We use an integrative approach to understand the molecular and genetic mechanisms that underlie risk for Tauopathies and other neurodegenerative diseases.

We primarily work with human iPSC lines differentiated into 3D organoids, as well as 2D mixed and monocultures of neurons, astrocytes and microglia, in order to model how disease-causing MAPT mutations affect cellular function. Computational work includes the generation and analysis of large 'omics datasets, and fine-mapping of human genetic data to understand the consequences of structural variation at the 17q21.31 "MAPT" locus.

The Bowles lab is committed to creating and maintaining an inclusive, diverse and highly collaborative environment. Click around to find out more about who we are and what we do, and feel free to get in touch!

Latest News

What's going on with the Bowles Lab?

18th April 2024

We chat about our Parkinson's UK funded work on the NoSPRIG podcast