We describe our new isogenic panel of MAPT S305 mutation iPSCs, which express high levels of 4R tau in vitro. We have developed a panel of 26 clones, derived from 4 parent lines, spanning 3 mutations (S305N, S305I and S305S), with control, heterozygous and homozygous mutations.

We all headed down to Harrogate for three days of all-things-DRI. Kathryn Newton was awarded an NC3Rs prize for her hard work leading organoid protocol bootcamps for researchers around the UK, and we all celebrated with a "Celestial" night out!

In collaboration with Cure-ND, the UK DRI is hosting a brand new symposium on using Stem Cells to model Neurodegenerative diseases! Registration and abstract submission are open to everyone through SCMND.com - come see us in Edinburgh in 2025!

Alex joins us to work on our Tauopathy Challenge Workshop project, focused on astrocyte pathology in PSP

We celebrated a little early, but September marks 2 full years of the Bowles lab!

We talk to Helga MacFarlane and Julie Jones about our Parkinson's UK funded work on LRRC37A2. Listen to it, and all other NoSPRIG podcasts HERE

The entire Bowles lab travelled to Washington DC to attend this year's Global Tau 2024, with a little side trip to NYC!

Dr. Dianne Lopez joins us as the second postdoc in the Bowles lab. She will be working on our Parkinson's UK funded project, looking at the role of LRRC37A2 in astrocytes, and how it might protect against Parkinson's risk.

We all headed down to Brighton for the UK DRI's annual conference. Our experience was complete with sessions around tau, genetics and EDI in the DRI, followed by Neon night!

The Bowles lab celebrates their first year!

We published a new pre-print, led by Dr. Taylor Bertucci in Dr. Sally Temple's lab, which describes their optimized method for the best QC steps and differentiation protocols for making reproducible and reliable forebrain organoids with high efficiency.

Lois Keavey joins us as a Research Assistant, while she is finishing up her Master's thesis. Lois will be working on our Tau Consortium-funded project to investigate the effects of neuron-astrocyte interactions in iPSC models of tauopathy.

We describe our new isogenic panel of MAPT S305 mutation iPSCs, which express high levels of 4R tau in vitro. We have developed a panel of 31 clones, derived from 4 parent lines, spanning 3 mutations (S305N, S305I and S305S), with control, heterozygous and homozygous mutations.

Our first PostDoc joined the lab! A huge welcome to Dr. Filipa Henderson-Sousa! Filipa will be working on our iPSC-organoid models to understand the role of ELAVL4 in tauopathy synaptic dysfunction.

Kat sat down with Molly Andrews at UK DRI headquarters to talk about starting up her lab and why tau is so great! In honour of International Women in Science Day, they also discuss the challenges and experiences of being women in academia

Today we welcome the very first Bowles lab member! Kathryn Newton joins us as our Senior Research Associate. Kathryn has extensive experience in culturing stem cells, and will be working to develop, optimise and validate organoid protocols.

Kat is teaming up with Dr. Catarina Silva as co-guest editor for a special edition of Biomedicines; "Tauopathies: New Perspectives and Challenges." We are looking for both review articles and original research to highlight in this special issue. Please get in touch with either Kat, Dr. Silva or the Biomedicines editorial board if you would like to be a contributor.

It starts today! The Bowles lab is officially established at the UK Dementia Research Institute at the University of Edinburgh!